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Modafinil Tablet has been shown to wake up healthy people and enhance their cognition. It is not a dopamine modulator and does not reduce impulsivity, but it improves memory, increases something called fluid intelligence, and makes tasks seem more pleasurable.
It can also increase vigilance and brighten moods. In studies of narcoleptic patients, it has reduced fatigue and slowed responses to stressful events.
What is Modafinil?
Modafinil has been evaluated for its waking effects, mood-brightening, and cognitive enhancement properties in several neurological and medical conditions (see the clinical trials summary below). It is particularly well tolerated in narcoleptic patients, has fewer side effects than amphetamine, and seems to be more effective than methylphenidate. It has also been used by the military to improve alertness and combat fatigue.
In rodents, modafinil dose- and delay-dependently enhances working memory performance on a sequential alternation task. Moreover, it increases extracellular levels of DA, NE, 5HT, and glutamate in the prefrontal cortex and hypothalamus. The elevations of these monoamines are attributed to the modulation of catecholamine systems by modafinil.
Human studies indicate that modafinil reduces errors on the WCST, but does not affect speed or accuracy in normal controls. However, among psychiatric populations, Modalert 200 Australia has been shown to improve attention and response inhibition in ADHD patients. Similarly, in two studies of obstructive sleep apnea, modafinil improved the scores of patients on a tension-anxiety index of the Profile of Mood States.
Furthermore, there is evidence that modafinil improves certain prefrontal cognitive functions in schizophrenia and major depression. In addition, it has been tested in patients with idiopathic hypersomnia, fibromyalgia, obstructive sleep apnea, chronic fatigue syndrome, polio, HIV infection, and dementias, with mixed results. Modafinil also has been used as a wakefulness agent to treat jet lag.
How is Modafinil used?
Modafinil is primarily used for the treatment of excessive sleepiness associated with narcolepsy. It has also been studied for other neurological and medical disorders that involve cognitive dysfunction, including multiple sclerosis, idiopathic Parkinson’s disease, chronic fatigue syndrome, obstructive sleep apnea, and fibromyalgia.
Modafinil is more effective than placebo at improving cognitive functions in these conditions. It has a unique mechanism of action compared to traditional psychostimulants. It does not elicit the same dopamine elevation in the nucleus accumbens of the brain that is responsible for the addictive properties of some other drugs.
Several studies have reported that modafinil increases performance on various cognitive tests in healthy adults who are not sleep-deprived. One randomized, placebo-controlled study found that modafinil 400 mg increased accuracy (relative to placebo) on the Wisconsin Card Sorting Task and reduced interference on the Stroop test after a night shift work simulation, comparable to 600 mg of caffeine and 20 mg of amphetamine.
Modafinil is also being studied for its wake-promoting effects in neuropsychiatric disorders and has been shown to improve symptoms in patients with ADD/ADHD. It is thought to act on the dopaminergic and norepinephrinergic systems similar to stimulants, although it may also influence the histaminergic system.
This system is involved in the regulation of stress responses and immune function. Recent studies have found that modafinil can increase serum C-reactive protein and reduce host resistance to Listeria monocytogenes, suggesting it has immunomodulating properties.
What are the side effects of Modafinil?
Modafinil ( Modawake 200 ) is known to cause several side effects. These include a slight increase in heart rate and blood pressure, nausea, diarrhea, and dry mouth. It is also believed to have an effect on certain neurochemicals in the brain, including dopamine, cAMP, and norepinephrine.
It is thought to act as a wakefulness agent by increasing neurotransmitter levels in the brain. Modafinil has also been shown to be able to boost mood and enhance memory in healthy individuals, so it is often used as a treatment for conditions such as Alzheimer’s disease, attention-deficit hyperactivity disorder (ADHD), depression, and idiopathic chronic fatigue syndrome. It is also commonly used by people who work night shifts or by students to stay awake and concentrate for long periods.
In a few clinical trials, modafinil has been found to improve decision-making and problem-solving skills. However, there is little research on the long-term effects of modafinil on these cognitive functions.
Modafinil is metabolized by the liver, primarily CYP3A4, and is eliminated in urine. Serum concentrations are decreased in the presence of drugs that induce CYP3A4, such as rifampin and phenytoin. Conversely, serum concentrations are increased with drugs that inhibit CYP3A4, such as azole antifungals (ketoconazole and itraconazole). Therefore, patients should avoid combining these medications. Taking modafinil in combination with these medicines could cause dangerously high levels of the drug in the body.
How should I take Modafinil?
Modafinil is take orally and may be take with or without food. It is usually take once a day in the morning for narcolepsy or 1 hour before work to treat shift work sleep disorder. It may be give for up to 12 weeks. Take this medication exactly as directed by your doctor. Follow the directions on your prescription label and ask your doctor or pharmacist to explain any part of it that you do not understand.
Modafinil decreases excessive daytime sleepiness in people with narcolepsy and improves wakefulness in some patients with other sleep disorders (such as obstructive sleep apnea/hypopnoea syndrome, and shift work sleep disorder). However, it does not cure these sleep disorders. It should not be use to treat tiredness caused by other conditions unless your doctor tells you to do so.
This drug can interact with certain medications and may cause serious side effects. Tell your doctor or pharmacist if you are taking any other drugs, including ones you buy without a prescription. Also tell your doctor if you have any allergies, especially to foods, preservatives, or dyes. Do not drink alcohol or use any other stimulants while taking this medicine. It can increase your blood pressure and heart rate, which could lead to dangerous or life-threatening effects.
Modafinil is very popular among ‘Type A’ high-achievers like entrepreneurs and students who are looking to get more done in a day. To maximize the cognitive enhancing and mood improvement benefits of this smart drug, we recommend using it with a high-quality nootropic stack such as NuClarity. This unique formula of natural brain supplements boosts choline levels and slows the breakdown of acetylcholine in your brain.
